mitochondrial ribosomal protein S27Genealiases: MRP-S27 · S27mt · mS27
Q-omics provides the consensus-scored MRPS27 profile across patient tissues and cancer cell-line models. MRPS27 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, MRPS27 is differentially expressed in 11, with the highest sampling consensus in COAD. Additionally, MRPS27 protein abundance shows 30,186 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight READ, COAD, and LSCC as cancer lineages where MRPS27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MRPS27 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MRPS27 survival associations across molecular data types. MRPS27 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (1) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MRPS27 RNA expression–survival associations across cancer types. High MRPS27 expression shows unfavorable associations in OV, KICH and SCLC, but favorable associations in READ, KIRC and LGG. The READ Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify READ as the clearest survival context for MRPS27 RNA expression.
This table summarizes MRPS27 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 12. The strongest signals are observed in COAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MRPS27. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MRPS27 shows higher tumor expression in COAD, LIHC, KIRP, LUAD, CHOL and LUSC. The COAD box plot shows higher MRPS27 RNA expression in tumor versus normal tissue (log2 FC = +0.722, t-test p < 0.001).
This table shows molecular features associated with MRPS27 in patient tissues and cancer cell lines. In patient samples, MRPS27 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, MRPS27 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in OVARY and UPPER_AERODIGESTIVE_TRACT.
