MRPS27

Across TCGA patient cohorts, MRPS27 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS27-associated genes across cancer lineages are MEK1, p62 Lck ligand, and ASNS. Each is linked with MRPS27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS27-to-partner and partner-to-MRPS27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MRPS27-low versus MRPS27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS27→partner) and Y-score (partner→MRPS27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.456	+2.736	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.363	+2.247	.002	.001	3	2
UCEC	ASNS →	+0.528	+2.222	<.001	.010	3	2
UCEC	C-Raf →	+0.141	+1.700	.007	.042	3	2
UCEC	EGFR_pY1068 →	-0.318	-2.736	<.001	<.001	3	1
UCEC	eIF4E →	+0.237	+2.247	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MEK1 by MRPS27 expression — UCEC

Explore this box plot interactively →