MRPS27

Across TCGA cell cohorts, MRPS27 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPS27-associated genes across cancer lineages are KRTAP5-11, MMP26, and C10orf53. Each is linked with MRPS27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS27-to-partner and partner-to-MRPS27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-11 grouped by MRPS27-low versus MRPS27-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS27→partner) and Y-score (partner→MRPS27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP5-11 →	+0.018	+5.209	<.001	.005	3	1
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.010	+3.217	.002	.006	3	1
LARGE_INTESTINE	C14orf180 →	+0.085	+3.155	.007	.008	3	1
LARGE_INTESTINE	SMIM33 →	+0.491	+3.426	.004	.007	3	1
LUNG_NSCLC_LUAD	SMIM28 →	+0.062	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KRTAP5-11 by MRPS27 expression — BLOOD_Lymphoma

Explore this box plot interactively →