MRPS27

Across TCGA pan-cancer cohorts, MRPS27 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MRPS27 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS27 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS27 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where MRPS27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.939	0.439	.003	11	view →
PDAC	DFS	Quartile	III,IV	0.545	0.896	.005	10	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	8	view →
OV	DFS	Median	All	1.000	0.810	.009	4	view →
LUAD	DFS	Quartile	II,III,IV	0.750	0.280	.014	4	view →
GBM	OS	Median	All	0.425	0.311	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MRPS27–LSCC (DFS)

Open the LSCC breakdown →