mannosidase alpha class 1B member 1Genealiases: ERMAN1 · ERManI · MANA-ER · MRT15
Q-omics provides the consensus-scored MAN1B1 profile across patient tissues and cancer cell-line models. MAN1B1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, MAN1B1 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, MAN1B1 protein abundance shows 19,263 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight BLCA, KIRC, and GBM as cancer lineages where MAN1B1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAN1B1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAN1B1 survival associations across molecular data types. MAN1B1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAN1B1 RNA expression–survival associations across cancer types. High MAN1B1 expression shows unfavorable associations in BLCA, ACC, LIHC, KIRC, MESO and COAD. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for MAN1B1 RNA expression.
This table summarizes MAN1B1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for MAN1B1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAN1B1 shows higher tumor expression in KIRC, HNSC, KIRP, COAD, LIHC and BLCA. The KIRC box plot shows higher MAN1B1 RNA expression in tumor versus normal tissue (log2 FC = +0.868, t-test p < 0.001).
This table shows molecular features associated with MAN1B1 in patient tissues and cancer cell lines. In patient samples, MAN1B1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, MAN1B1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and CNS.
