MAN1B1

Across TCGA patient cohorts, MAN1B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,139 significant associations in total. OV shows the largest number of these associations.

The most reproducible MAN1B1-associated GO terms across cancer lineages are Protein localization to ciliary transition zone, Nucleotide-sugar biosynthetic process, and Regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Each is linked with MAN1B1 in more than 19 cancer types. Because this analysis shows association rather than direction, both MAN1B1-to-partner and partner-to-MAN1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to ciliary transition zone grouped by MAN1B1-low versus MAN1B1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1B1→partner) and Y-score (partner→MAN1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein localization to ciliary transition zone →	+0.058	+0.545	<.001	<.001	3	20
SCLC	Nucleotide-sugar biosynthetic process →	+0.088	+0.522	<.001	<.001	3	20
THYM	Regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning →	+0.045	+0.467	<.001	<.001	3	18
LAML	Response to fungicide →	+0.057	+0.495	<.001	<.001	3	18
TGCT	Smoothened signaling pathway involved in dorsal/ventral neural tube patterning →	+0.069	+0.387	<.001	<.001	3	17
ACC	5S class rRNA transcription by RNA polymerase III →	+0.063	+1.205	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,139 associations by consensus.

Protein localization to ciliary transition zone by MAN1B1 expression — ESCA

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