MAN1B1

Across TCGA cell cohorts, MAN1B1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAN1B1-associated genes across cancer lineages are GJD4, RAB19, and LRP1B. Each is linked with MAN1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN1B1-to-partner and partner-to-MAN1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD4 grouped by MAN1B1-low versus MAN1B1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1B1→partner) and Y-score (partner→MAN1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GJD4 →	+0.040	+4.430	<.001	<.001	3	2
BLOOD_Leukemia	RAB19 →	+0.440	+3.594	.007	.007	3	1
BLOOD_Leukemia	LRP1B →	+0.364	+4.141	<.001	.001	3	1
BLOOD_Leukemia	OR10Q1 →	+0.016	+3.969	<.001	.009	3	1
BLOOD_Leukemia	C5orf38 →	+1.263	+3.885	.001	.003	3	1
BLOOD_Leukemia	SERPINB11 →	+0.021	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GJD4 by MAN1B1 expression — BLOOD_Leukemia

Explore this box plot interactively →