serpin family B member 11Genealiases: EPIPIN · SERPIN11
Q-omics provides the consensus-scored SERPINB11 profile across patient tissues and cancer cell-line models. SERPINB11 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SERPINB11 is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, SERPINB11 RNA expression shows 5,951 significant pathway-activity associations, with the highest sampling consensus in PRAD. Together, these results highlight KIRP, HNSC, and PRAD as cancer lineages where SERPINB11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SERPINB11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SERPINB11 survival associations across molecular data types. SERPINB11 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SERPINB11 RNA expression–survival associations across cancer types. High SERPINB11 expression shows unfavorable associations in KIRP, BRCA, DLBC and THCA, but favorable associations in CESC and LUSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SERPINB11 RNA expression.
This table summarizes SERPINB11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SERPINB11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SERPINB11 shows lower tumor expression in HNSC, COAD, PRAD, READ and BRCA and higher tumor expression in LUSC. The HNSC box plot shows higher SERPINB11 RNA expression in normal versus tumor tissue (log2 FC = −1.728, t-test p < 0.001).
This table shows molecular features associated with SERPINB11 in patient tissues and cancer cell lines. In patient samples, SERPINB11 shows the broadest associations at the RNA and protein expression levels, with PRAD recurring as the lineage with the largest associated feature set. In cancer cell lines, SERPINB11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
