MAN1B1

Across TCGA pan-cancer cohorts, MAN1B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MAN1B1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MAN1B1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAN1B1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where MAN1B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.288	0.809	<.001	53	view →
PDAC	DFS	Median	III,IV	0.208	0.481	.002	44	view →
LSCC	OS	Quartile	All	0.588	0.932	.001	31	view →
LUAD	OS	Tertile	II,III,IV	0.300	0.839	.026	8	view →
UCEC	OS	Median	All	0.984	0.913	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MAN1B1–CCRCC (DFS)

Open the CCRCC breakdown →