MAN1B1

Across TCGA patient cohorts, MAN1B1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN1B1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and NF2. Each is linked with MAN1B1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAN1B1-to-partner and partner-to-MAN1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAN1B1-low versus MAN1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1B1→partner) and Y-score (partner→MAN1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.669	+2.720	.003	.003	3	4
UCEC	eIF4E →	+0.215	+2.321	.007	.005	3	2
UCEC	NF2 →	+0.234	+1.874	.004	.049	3	2
UCEC	Rad50 →	-0.232	-1.861	.012	.049	3	2
UCEC	Annexin-1 →	+0.639	+2.700	.001	.005	3	2
UCEC	VEGFR2 →	+0.242	+1.916	.034	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by MAN1B1 expression — UCEC

Explore this box plot interactively →