MAN1B1

Across TCGA pan-cancer cohorts, MAN1B1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MAN1B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAN1B1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MAN1B1 is over-expressed in tumor.

HNSC, CCRCC, and COAD are the cancer types where MAN1B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAN1B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.558	<.001	12	view →
CCRCC	Male	II,III,IV	+0.455	<.001	11	view →
COAD	All	III,IV	+0.240	<.001	9	view →
LSCC	Male	III,IV	+0.571	<.001	8	view →
LUAD	Female	All	+0.269	<.001	8	view →
OV	All	All	+0.332	.022	2	view →
PDAC	All	IV	+0.657	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MAN1B1–HNSC

Open the HNSC breakdown →