MAN1B1

Across TCGA patient cohorts, MAN1B1 mutation is significantly associated with the RNA expression of many other genes, with 2,810 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN1B1-associated genes across cancer lineages are H2BL1P, AP1B1P2, and MIRLET7G. Each is linked with MAN1B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN1B1-to-partner and partner-to-MAN1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BL1P grouped by MAN1B1-low versus MAN1B1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1B1→partner) and Y-score (partner→MAN1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H2BL1P →	+0.129	+6.112	<.001	.002	3	3
UCEC	AP1B1P2 →	+0.092	+2.847	.001	.008	3	3
COAD	MIRLET7G →	+0.499	+3.412	.007	.006	3	2
COAD	MIR4477A →	+0.289	+5.142	<.001	.002	3	2
BRCA	RN7SL140P →	+0.167	+6.639	<.001	.001	3	2
CESC	IGLJ7 →	+0.506	+3.507	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,810 associations by consensus.

H2BL1P by MAN1B1 expression — BRCA

Explore this box plot interactively →