Q-omics provides the consensus-scored LSP1 profile across patient tissues and cancer cell-line models. LSP1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, LSP1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, LSP1 protein abundance shows 26,562 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, KIRC, and LSCC as cancer lineages where LSP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LSP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LSP1 survival associations across molecular data types. LSP1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LSP1 RNA expression–survival associations across cancer types. High LSP1 expression shows unfavorable associations in MESO and LGG, but favorable associations in HNSC, UCEC, SKCM and CESC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for LSP1 RNA expression.
This table summarizes LSP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 10. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for LSP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LSP1 shows lower tumor expression in BLCA, COAD, LUSC and UCEC and higher tumor expression in KIRC and KIRP. The KIRC box plot shows higher LSP1 RNA expression in tumor versus normal tissue (log2 FC = +2.440, t-test p < 0.001).
This table shows molecular features associated with LSP1 in patient tissues and cancer cell lines. In patient samples, LSP1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, LSP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BONE.
