LSP1

Across TCGA cell cohorts, LSP1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LSP1-associated genes across cancer lineages are OR8A1, OR8B8, and OR8B2. Each is linked with LSP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSP1-to-partner and partner-to-LSP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8A1 grouped by LSP1-low versus LSP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSP1→partner) and Y-score (partner→LSP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR8A1 →	+0.392	+5.201	<.001	.006	3	2
BLOOD_Leukemia	OR8B8 →	+0.018	+5.201	.006	.006	3	2
BLOOD_Leukemia	OR8B2 →	+0.059	+5.969	<.001	.001	3	2
BLOOD_Leukemia	OR8D1 →	+0.162	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR8G1 →	+0.153	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR8D2 →	+0.148	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR8A1 by LSP1 expression — BLOOD_Leukemia

Explore this box plot interactively →