LSP1

Across TCGA pan-cancer cohorts, LSP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LSP1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LSP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LSP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

COAD, HNSC, and LUAD are the cancer types where LSP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	66	view →
HNSC	DFS	Tertile	III,IV	0.459	0.777	.006	12	view →
LUAD	OS	Tertile	II,III,IV	0.893	0.364	.004	10	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.587	.034	4	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.793	.046	1	view →
LSCC	DFS	Tertile	All	0.887	0.535	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LSP1–COAD (DFS)

Open the COAD breakdown →