LDL receptor related protein 1Genealiases: A2MR · APOER · APR · CD91 · DDH3 · IGFBP-3R
Q-omics provides the consensus-scored LRP1 profile across patient tissues and cancer cell-line models. LRP1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, LRP1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, LRP1 protein abundance shows 27,211 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight BLCA, KIRC, and LSCC as cancer lineages where LRP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LRP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LRP1 survival associations across molecular data types. LRP1 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (6) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LRP1 RNA expression–survival associations across cancer types. High LRP1 expression shows unfavorable associations in BLCA, OV, LIHC and MESO, but favorable associations in HNSC and UCS. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for LRP1 RNA expression.
This table summarizes LRP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for LRP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LRP1 shows lower tumor expression in BLCA, UCEC and BRCA and higher tumor expression in KIRC, HNSC and KIRP. The KIRC box plot shows higher LRP1 RNA expression in tumor versus normal tissue (log2 FC = +1.569, t-test p < 0.001).
This table shows molecular features associated with LRP1 in patient tissues and cancer cell lines. In patient samples, LRP1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, LRP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and CNS.
