LRP1

Across TCGA cell cohorts, LRP1 mutation is significantly associated with the RNA expression of many other genes, with 4,330 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP1-associated genes across cancer lineages are NLRP6, LYG1, and ZNF837. Each is linked with LRP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRP1-to-partner and partner-to-LRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP6 grouped by LRP1-low versus LRP1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP1→partner) and Y-score (partner→LRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NLRP6 →	+0.048	+4.000	<.001	.001	3	4
LARGE_INTESTINE	LYG1 →	+1.103	+2.628	<.001	<.001	3	4
BLOOD_Leukemia	ZNF837 →	+0.512	+2.029	<.001	.002	3	4
LARGE_INTESTINE	B3GNT4 →	+0.860	+2.003	<.001	<.001	3	4
BLOOD_Leukemia	DHX40 →	+0.580	+3.228	<.001	.004	3	3
BLOOD_Leukemia	RSPH4A →	+0.156	+1.833	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,330 associations by consensus.

NLRP6 by LRP1 expression — LIVER

Explore this box plot interactively →