LRP1

Across TCGA pan-cancer cohorts, LRP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRP1 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where LRP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.569	<.001	11	view →
HNSC	Female	II,III,IV	+1.446	<.001	9	view →
BLCA	Male	All	−1.572	<.001	7	view →
UCEC	All	All	−1.880	<.001	6	view →
BRCA	All	All	−1.353	<.001	6	view →
KIRP	All	All	+0.714	.003	6	view →
KICH	All	All	−1.235	<.001	5	view →
THCA	All	II,III,IV	−0.611	.004	4	view →
LUAD	Female	All	−0.730	<.001	3	view →
LUSC	All	All	−0.610	<.001	2	view →
STAD	Male	IV	+1.299	.026	1	view →
COAD	Female	II,III,IV	−0.630	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRP1–KIRC

Open the KIRC breakdown →