LRP1

Across TCGA pan-cancer cohorts, LRP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRP1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRP1 expression acts as an unfavorable survival marker.

CCRCC, UCEC, and LSCC are the cancer types where LRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.614	0.864	<.001	118	view →
UCEC	OS	Median	II,III,IV	0.620	1.000	.011	34	view →
LSCC	DFS	Quartile	II,III,IV	0.487	0.939	.005	20	view →
LUAD	DFS	Median	III,IV	0.485	0.995	.003	12	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRP1–CCRCC (DFS)

Open the CCRCC breakdown →