LRP1

Across TCGA patient cohorts, LRP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,061 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LRP1-associated proteins across cancer lineages are PCOLCE, ISLR, and VCAN_S2116. Each is linked with LRP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both LRP1-to-partner and partner-to-LRP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRP1 versus PCOLCE in LSCC, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP1→partner) and Y-score (partner→LRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PCOLCE →	+0.815	+0.848	<.001	<.001	3	9
OV	ISLR →	+0.932	+1.808	<.001	<.001	3	9
LSCC	VCAN_S2116 →	+1.246	+0.733	<.001	<.001	3	9
BRCA	TIMP2 →	+0.815	+1.033	<.001	<.001	3	9
BRCA	AP2A1 →	+0.255	+0.971	<.001	.001	3	8
HNSC	COL3A1 →	+0.988	+0.872	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,061 associations by consensus.

LRP1 vs PCOLCE — LSCC

Explore this scatter interactively →