LRP1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LRP1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,146 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LRP1-associated genes across cancer lineages are SRPX, MMP2, and IFFO1. Each is linked with LRP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both LRP1-to-partner and partner-to-LRP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRP1 versus SRPX in BRCA, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP1→partner) and Y-score (partner→LRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASRPX →+1.497+0.657<.001<.001310
OVMMP2 →+2.219+0.578<.001<.001310
OVIFFO1 →+1.083+0.622<.001<.00139
OVPCOLCE →+1.421+0.537<.001<.00139
OVSFRP4 →+2.523+0.630<.001<.00139
GBMMEOX2 →+1.943+0.339<.001.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,146 associations by consensus.

LRP1 vs SRPX — BRCA

Per-sample scatter of LRP1 vs SRPX in BRCA (Pearson r = 0.73).

Explore this scatter interactively →

Exploration