LRP1

Across TCGA patient cohorts, LRP1 mutation is significantly associated with the total protein of many other genes, with 101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP1-associated genes across cancer lineages are PKC-b-II_pS660, Cyclin-B1, and PCNA. Each is linked with LRP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRP1-to-partner and partner-to-LRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by LRP1-low versus LRP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP1→partner) and Y-score (partner→LRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.359	-1.991	<.001	<.001	3	5
UCEC	Cyclin-B1 →	+0.473	+1.103	<.001	<.001	3	5
STAD	PCNA →	+0.216	+2.321	.027	.030	3	5
COAD	Caspase-7-cleavedD198 →	+1.133	+3.186	<.001	<.001	3	5
STAD	ASNS →	+0.430	+2.662	.004	<.001	3	4
COAD	Mre11 →	+0.090	+1.765	.009	.010	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

PKC-b-II_pS660 by LRP1 expression — COAD

Explore this box plot interactively →