potassium voltage-gated channel subfamily Q member 5Genealiases: Kv7.5 · MRD46
Q-omics provides the consensus-scored KCNQ5 profile across patient tissues and cancer cell-line models. KCNQ5 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, KCNQ5 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, KCNQ5 RNA expression shows 17,768 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight MESO, COAD, and THYM as cancer lineages where KCNQ5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNQ5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNQ5 survival associations across molecular data types. KCNQ5 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNQ5 RNA expression–survival associations across cancer types. High KCNQ5 expression shows unfavorable associations in MESO and BLCA, but favorable associations in LIHC, UVM, ESCA and LAML. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for KCNQ5 RNA expression.
This table summarizes KCNQ5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for KCNQ5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNQ5 shows lower tumor expression in COAD and UCEC and higher tumor expression in LUAD, KICH, KIRC and LUSC. The COAD box plot shows higher KCNQ5 RNA expression in normal versus tumor tissue (log2 FC = −0.417, t-test p < 0.001).
This table shows molecular features associated with KCNQ5 in patient tissues and cancer cell lines. In patient samples, KCNQ5 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNQ5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BLOOD_Lymphoma.
