Across TCGA patient cohorts, KCNQ5 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNQ5-associated genes across cancer lineages are 4E-BP1, eIF4E, and FASN. Each is linked with KCNQ5 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNQ5-to-partner and partner-to-KCNQ5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ5→partner) and Y-score (partner→KCNQ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.391	+3.169	.001	.018	3	4
UCEC	eIF4E →	+0.169	+2.321	.006	<.001	3	4
STAD	FASN →	+0.403	+2.823	.020	.034	2	4
STAD	Akt →	-0.269	-3.321	.040	.009	3	3
COAD	Caspase-7-cleavedD198 →	+1.098	+3.717	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.581	+1.485	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Exploration

KCNQ5 survival (RNA) · tumor vs normal (RNA) · all KCNQ5 data types