Across TCGA pan-cancer cohorts, KCNQ5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KCNQ5’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where KCNQ5 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNQ5 is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.
COAD, LUAD, and KICH are the cancer types where KCNQ5 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNQ5 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.