Across TCGA pan-cancer cohorts, KCNQ5 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KCNQ5 data layer compared with 23 for mass-spec protein.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KCNQ5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNQ5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.
LUSC, UCEC, and PRAD are the cancer types where KCNQ5 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.