Q-omics provides the consensus-scored HLA-B profile across patient tissues and cancer cell-line models. HLA-B expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, HLA-B is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, HLA-B RNA expression shows 15,448 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight SKCM, KIRC, and UVM as cancer lineages where HLA-B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HLA-B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HLA-B survival associations across molecular data types. HLA-B RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HLA-B RNA expression–survival associations across cancer types. High HLA-B expression shows unfavorable associations in UVM, LGG and THYM, but favorable associations in SKCM, SCLC and CESC. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for HLA-B RNA expression.
This table summarizes HLA-B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HLA-B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HLA-B shows lower tumor expression in LUSC and higher tumor expression in KIRC, HNSC, KIRP, THCA and STAD. The KIRC box plot shows higher HLA-B RNA expression in tumor versus normal tissue (log2 FC = +2.261, t-test p < 0.001).
This table shows molecular features associated with HLA-B in patient tissues and cancer cell lines. In patient samples, HLA-B shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, HLA-B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and SOFT_TISSUE.
