HLA-B

Across TCGA patient cohorts, HLA-B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-B-associated genes across cancer lineages are JNK_pT183_Y185, STAT3_pY705, and VHL. Each is linked with HLA-B in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-B-to-partner and partner-to-HLA-B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by HLA-B-low versus HLA-B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-B→partner) and Y-score (partner→HLA-B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.233	-3.156	.011	.020	3	1
UCEC	STAT3_pY705 →	-0.522	-3.169	<.001	.020	3	1
UCEC	VHL →	-1.131	-3.169	.002	.019	3	1
UCEC	C-Raf →	+0.195	+3.169	.013	.020	3	1
UCEC	Notch1 →	+0.200	+2.817	.009	.036	2	1
UCEC	PKC-a →	+0.446	+3.169	.045	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by HLA-B expression — UCEC

Explore this box plot interactively →