HLA-B

Across TCGA pan-cancer cohorts, HLA-B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HLA-B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-B is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where HLA-B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.261	<.001	12	view →
HNSC	All	IV	+1.596	<.001	12	view →
KIRP	Male	All	+1.259	<.001	9	view →
THCA	Male	II,III,IV	+1.809	<.001	8	view →
LUSC	Male	II,III,IV	−1.263	<.001	8	view →
STAD	All	II,III,IV	+1.547	<.001	6	view →
LUAD	All	All	−0.457	.001	6	view →
ESCA	All	All	+1.922	.001	5	view →
LIHC	All	All	+0.671	.004	4	view →
BRCA	All	All	+0.364	.002	4	view →
CHOL	All	All	+1.716	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HLA-B–KIRC

Open the KIRC breakdown →