HLA-B

Across TCGA pan-cancer cohorts, HLA-B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HLA-B data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-B RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-B expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

SKCM, UVM, and LGG are the cancer types where HLA-B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.402	0.273	<.001	124	view →
UVM	DFS	Median	All	0.431	0.745	<.001	70	view →
LGG	OS	Median	All	0.372	0.512	<.001	46	view →
SCLC	DFS	Tertile	All	0.821	0.462	<.001	44	view →
THYM	DFS	Quartile	II,III,IV	0.460	0.936	<.001	42	view →
CESC	OS	Median	II,III,IV	0.910	0.730	.001	42	view →
READ	OS	Median	IV	0.834	0.443	.003	36	view →
THCA	OS	Tertile	All	1.000	0.961	.004	24	view →
SARC	OS	Median	All	0.862	0.662	.002	23	view →
LUSC	DFS	Tertile	II,III,IV	0.508	0.687	.006	22	view →
DLBC	DFS	Median	II,III,IV	0.477	1.000	.005	15	view →
HNSC	OS	Quartile	All	0.317	0.504	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HLA-B–SKCM (OS)

Open the SKCM breakdown →