HLA-B

Across TCGA patient cohorts, HLA-B protein abundance is significantly associated with the RNA expression of many other genes, with 6,642 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-B-associated genes across cancer lineages are HCP5, PSMB9, and BTN3A3. Each is linked with HLA-B in more than 7 cancer types. Because this analysis shows association rather than direction, both HLA-B-to-partner and partner-to-HLA-B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-B versus HCP5 in BRCA, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-B→partner) and Y-score (partner→HLA-B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HCP5 →	+0.995	+0.833	<.001	<.001	3	8
UCEC	PSMB9 →	+1.143	+0.645	<.001	.003	3	8
COAD	BTN3A3 →	+0.859	+0.672	<.001	<.001	3	7
HNSC	STAT1 →	+1.110	+0.562	<.001	<.001	3	7
HNSC	GBP1 →	+1.421	+0.477	<.001	<.001	3	7
HNSC	CXCL9 →	+1.902	+0.627	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,642 associations by consensus.

HLA-B vs HCP5 — BRCA

Explore this scatter interactively →