HLA-B

Across TCGA patient cohorts, HLA-B mutation is significantly associated with the RNA expression of many other genes, with 625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-B-associated genes across cancer lineages are RNU6-939P, IPPKP1, and RN7SL275P. Each is linked with HLA-B in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-B-to-partner and partner-to-HLA-B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-939P grouped by HLA-B-low versus HLA-B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-B→partner) and Y-score (partner→HLA-B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-939P →	+0.342	+4.837	<.001	<.001	3	2
CESC	IPPKP1 →	+0.033	+3.539	.002	.003	3	2
CESC	RN7SL275P →	+0.074	+2.746	.005	.009	3	2
SKCM	RNU6-822P →	+0.277	+3.717	<.001	.005	3	2
UCEC	MIR7702 →	+0.338	+4.890	<.001	.002	3	2
UCEC	MIR4734 →	+0.454	+2.961	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 625 associations by consensus.

RNU6-939P by HLA-B expression — CESC

Explore this box plot interactively →