HIC ZBTB transcriptional repressor 1Genealiases: ZBTB29 · ZNF901 · hic-1
Q-omics provides the consensus-scored HIC1 profile across patient tissues and cancer cell-line models. HIC1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, HIC1 is differentially expressed in 16, with the highest sampling consensus in BLCA. Additionally, HIC1 protein abundance shows 21,614 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight UVM, BLCA, and LSCC as cancer lineages where HIC1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HIC1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HIC1 survival associations across molecular data types. HIC1 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (2) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HIC1 RNA expression–survival associations across cancer types. High HIC1 expression shows unfavorable associations in UVM, KIRP, ACC and MESO, but favorable associations in UCEC and CHOL. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for HIC1 RNA expression.
This table summarizes HIC1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 5. The strongest signals are observed in BLCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HIC1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HIC1 shows lower tumor expression in BLCA, UCEC, THCA and LUSC and higher tumor expression in KIRC and HNSC. The BLCA box plot shows higher HIC1 RNA expression in normal versus tumor tissue (log2 FC = −1.801, t-test p < 0.001).
This table shows molecular features associated with HIC1 in patient tissues and cancer cell lines. In patient samples, HIC1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, HIC1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OVARY and SOFT_TISSUE.
