HIC1

Across TCGA cell cohorts, HIC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,506 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HIC1-associated GO terms across cancer lineages are Anterograde neuronal dense core vesicle transport, Positive regulation of establishment of T cell polarity, and Negative regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with HIC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HIC1-to-partner and partner-to-HIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anterograde neuronal dense core vesicle transport grouped by HIC1-low versus HIC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC1→partner) and Y-score (partner→HIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Anterograde neuronal dense core vesicle transport →	+0.233	+0.829	<.001	.006	3	10
LUNG_NSCLC_LUSC	Positive regulation of establishment of T cell polarity →	+0.314	+1.274	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of intracellular steroid hormone receptor signaling pathway →	+0.059	+0.774	<.001	.005	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of fibroblast proliferation →	+0.090	+0.762	<.001	.001	3	9
BONE	Positive regulation of cell-substrate adhesion →	+0.128	+1.013	.001	<.001	3	9
URINARY_TRACT	Action potential propagation →	+1.217	+1.018	<.001	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,506 associations by consensus.

Anterograde neuronal dense core vesicle transport by HIC1 expression — BONE

Explore this box plot interactively →