HIC1

Across TCGA pan-cancer cohorts, HIC1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HIC1 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HIC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HIC1 expression acts as an unfavorable survival marker.

LUSC and UCEC are the cancer types where HIC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.112	0.776	<.001	36	view →
UCEC	OS	Median	III,IV	0.066	0.830	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HIC1–LUSC (OS)

Open the LUSC breakdown →