HIC1

Across TCGA patient cohorts, HIC1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIC1-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and Paxillin. Each is linked with HIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIC1-to-partner and partner-to-HIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by HIC1-low versus HIC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC1→partner) and Y-score (partner→HIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.127	-2.459	.035	.020	3	2
UCEC	mTOR_pS2448 →	-0.168	-2.459	.019	.020	3	1
UCEC	Paxillin →	-0.256	-3.160	.040	.019	3	1
UCEC	AR →	-0.423	-2.459	.019	.020	3	1
UCEC	CD31 →	+0.209	+2.331	.003	.019	3	1
UCEC	C-Raf_pS338 →	-0.080	-3.584	.042	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FOXO3a_pS318_S321 by HIC1 expression — UCEC

Explore this box plot interactively →