HIC1

Across TCGA patient cohorts, HIC1 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIC1-associated genes across cancer lineages are LINC01050, TM4SF19-TCTEX1D2, and GTF2F2P2. Each is linked with HIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIC1-to-partner and partner-to-HIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01050 grouped by HIC1-low versus HIC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC1→partner) and Y-score (partner→HIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01050 →	+0.213	+2.479	.002	.003	3	1
UCEC	TM4SF19-TCTEX1D2 →	+0.104	+3.724	.003	.001	3	1
COAD	GTF2F2P2 →	+0.168	+5.790	.006	.003	3	1
COAD	OR52X1P →	+0.072	+5.145	.002	.007	3	1
COAD	RNU5A-3P →	+0.554	+5.080	.002	.008	3	1
UCEC	SLAMF9 →	+0.504	+3.617	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

LINC01050 by HIC1 expression — UCEC

Explore this box plot interactively →