HIC1

Across TCGA pan-cancer cohorts, HIC1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HIC1 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HIC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HIC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where HIC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.846	0.264	.006	17	view →
LUAD	DFS	Quartile	II,III,IV	0.741	0.281	.010	10	view →
LSCC	OS	Median	II,III,IV	0.908	0.811	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HIC1–CCRCC (DFS)

Open the CCRCC breakdown →