HIC1

Across TCGA cell cohorts, HIC1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HIC1-associated genes across cancer lineages are SPINK9, SLC5A4, and PRMT8. Each is linked with HIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIC1-to-partner and partner-to-HIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by HIC1-low versus HIC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC1→partner) and Y-score (partner→HIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1
BLOOD_Leukemia	SLC5A4 →	+0.274	+3.793	<.001	<.001	3	1
BLOOD_Leukemia	PRMT8 →	+0.290	+3.561	<.001	<.001	3	1
BLOOD_Leukemia	HPCAL4 →	+0.270	+3.478	<.001	.006	3	1
BLOOD_Leukemia	ELOVL4 →	+1.818	+3.292	.003	.007	3	1
BLOOD_Leukemia	OR11H1 →	+0.051	+3.464	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

SPINK9 by HIC1 expression — SKIN

Explore this box plot interactively →