family with sequence similarity 149 member AGenealiases: MST119 · MSTP119
Q-omics provides the consensus-scored FAM149A profile across patient tissues and cancer cell-line models. FAM149A expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, FAM149A is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, FAM149A RNA expression shows 17,336 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRP, HNSC, and THYM as cancer lineages where FAM149A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM149A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM149A survival associations across molecular data types. FAM149A RNA expression shows survival associations in the most cancer types (21), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM149A RNA expression–survival associations across cancer types. High FAM149A expression shows unfavorable associations in BLCA and HNSC, but favorable associations in KIRP, UCEC, BRCA and SARC. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for FAM149A RNA expression.
This table summarizes FAM149A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for FAM149A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM149A shows lower tumor expression in HNSC, BLCA, THCA, KICH, LUSC and LUAD. The HNSC box plot shows higher FAM149A RNA expression in normal versus tumor tissue (log2 FC = −1.007, t-test p < 0.001).
This table shows molecular features associated with FAM149A in patient tissues and cancer cell lines. In patient samples, FAM149A shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM149A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and LARGE_INTESTINE.
