FAM149A

Across TCGA pan-cancer cohorts, FAM149A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM149A data layer compared with 21 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher FAM149A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM149A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, COAD, and SKCM are the cancer types where FAM149A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.224	0.729	.007	15	view →
COAD	OS	Median	All	0.556	0.870	.017	6	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →
UCEC	DFS	Median	All	0.943	0.635	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM149A–STAD (OS)

Open the STAD breakdown →