FAM149A

Across TCGA pan-cancer cohorts, FAM149A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM149A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM149A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM149A is over-expressed in tumor, although a few such as HNSC and BLCA show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where FAM149A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM149A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.007	<.001	11	view →
BLCA	Male	IV	−2.724	<.001	10	view →
THCA	Female	II,III,IV	−0.587	<.001	10	view →
KICH	Female	III,IV	−3.680	<.001	9	view →
LUSC	Female	II,III,IV	−1.895	<.001	9	view →
LUAD	All	All	−0.516	<.001	7	view →
STAD	Female	All	−1.884	<.001	6	view →
BRCA	All	III,IV	−1.716	<.001	6	view →
LIHC	All	II,III,IV	−0.782	<.001	6	view →
READ	Female	All	−1.989	<.001	5	view →
KIRC	Female	III,IV	+0.843	<.001	4	view →
COAD	All	All	−0.562	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FAM149A–HNSC

Open the HNSC breakdown →