FAM149A

Across TCGA pan-cancer cohorts, FAM149A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM149A data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher FAM149A RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM149A expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCEC show a favorable association.

KIRP, UCEC, and BRCA are the cancer types where FAM149A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.829	0.567	<.001	73	view →
UCEC	OS	Median	All	0.956	0.897	<.001	54	view →
BRCA	OS	Tertile	III,IV	0.921	0.762	.001	34	view →
SARC	DFS	Tertile	All	0.707	0.517	.006	20	view →
BLCA	OS	Quartile	IV	0.142	0.529	.004	18	view →
HNSC	OS	Tertile	All	0.163	0.478	.001	17	view →
LIHC	OS	Quartile	All	0.803	0.576	<.001	16	view →
MESO	OS	Quartile	All	0.487	0.226	.007	14	view →
SKCM	DFS	Quartile	All	0.682	0.551	.011	13	view →
LUSC	OS	Quartile	All	0.624	0.734	.018	13	view →
COAD	DFS	Quartile	III,IV	0.442	0.818	.012	12	view →
KICH	OS	Median	All	1.000	0.924	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FAM149A–KIRP (OS)

Open the KIRP breakdown →