FAM149A

Across TCGA patient cohorts, FAM149A mutation is significantly associated with the RNA expression of many other genes, with 1,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM149A-associated genes across cancer lineages are RNU6-1067P, COL4A5, and RNA5SP146. Each is linked with FAM149A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM149A-to-partner and partner-to-FAM149A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1067P grouped by FAM149A-low versus FAM149A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM149A→partner) and Y-score (partner→FAM149A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1067P →	+0.614	+4.685	<.001	.007	3	2
UCEC	COL4A5 →	-0.983	-3.451	<.001	.005	3	2
UCEC	RNA5SP146 →	+0.222	+2.332	<.001	.001	3	2
UCEC	RN7SL354P →	+0.191	+1.736	<.001	.005	3	2
UCEC	IGKV1-27 →	+1.882	+2.700	<.001	.005	3	2
COAD	RPS14P7 →	+0.183	+5.187	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

RNU6-1067P by FAM149A expression — BLCA

Explore this box plot interactively →