FAM149A

Across TCGA patient cohorts, FAM149A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM149A-associated genes across cancer lineages are PCNA, PEA-15_pS116, and ASNS. Each is linked with FAM149A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM149A-to-partner and partner-to-FAM149A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FAM149A-low versus FAM149A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM149A→partner) and Y-score (partner→FAM149A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.225	+2.222	.014	.011	3	2
UCEC	PEA-15_pS116 →	+0.360	+2.999	.015	.035	3	2
UCEC	ASNS →	+0.367	+2.321	.016	.034	3	2
UCEC	EGFR_pY1068 →	-0.263	-2.321	.013	.033	3	1
UCEC	eIF4E →	+0.214	+3.459	.016	.005	3	1
UCEC	A-Raf_pS299 →	-0.182	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PCNA by FAM149A expression — UCEC

Explore this box plot interactively →