Q-omics provides the consensus-scored CORIN profile across patient tissues and cancer cell-line models. CORIN expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, CORIN is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, CORIN RNA expression shows 17,766 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LIHC, COAD, and UVM as cancer lineages where CORIN shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CORIN — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CORIN survival associations across molecular data types. CORIN RNA expression shows survival associations in the most cancer types (21), followed by mutation status (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CORIN RNA expression–survival associations across cancer types. High CORIN expression shows unfavorable associations in LIHC, LGG, STAD, UVM and SARC, but favorable associations in LUAD. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify LIHC as the clearest survival context for CORIN RNA expression.
This table summarizes CORIN tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for CORIN. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CORIN shows lower tumor expression in KIRC, KICH and KIRP and higher tumor expression in COAD, BRCA and LIHC. The COAD box plot shows higher CORIN RNA expression in tumor versus normal tissue (log2 FC = +0.945, t-test p < 0.001).
This table shows molecular features associated with CORIN in patient tissues and cancer cell lines. In patient samples, CORIN shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, CORIN RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
