CORIN

Across TCGA cell cohorts, CORIN RNA expression is significantly associated with the go_rna of many other GO terms, with 1,787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CORIN-associated GO terms across cancer lineages are Membrane protein intracellular domain proteolysis, Chemical synaptic transmission, postsynaptic, and Intrinsic apoptotic signaling pathway. Each is linked with CORIN in more than 8 cancer types. Because this analysis shows association rather than direction, both CORIN-to-partner and partner-to-CORIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane protein intracellular domain proteolysis grouped by CORIN-low versus CORIN-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CORIN→partner) and Y-score (partner→CORIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Membrane protein intracellular domain proteolysis →	+0.102	+0.125	<.001	<.001	3	9
PANCREAS	Chemical synaptic transmission, postsynaptic →	-0.051	-0.209	.004	.008	3	7
BONE	Intrinsic apoptotic signaling pathway →	+0.063	+0.504	.001	.007	3	7
KIDNEY	Regulation of macroautophagy →	+0.042	+0.154	<.001	<.001	3	7
SKIN	Regulation of protein exit from endoplasmic reticulum →	+0.096	+0.191	<.001	<.001	3	7
SKIN	Germ cell development →	-0.034	-0.201	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,787 associations by consensus.

Membrane protein intracellular domain proteolysis by CORIN expression — KIDNEY

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