CORIN

Across TCGA pan-cancer cohorts, CORIN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CORIN data layer compared with 8 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher CORIN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CORIN expression acts as an unfavorable survival marker, although some lineages such as LUAD and LAML show a favorable association.

LIHC, LUAD, and LGG are the cancer types where CORIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.455	0.634	.001	43	view →
LUAD	DFS	Median	III,IV	0.646	0.342	.005	29	view →
LGG	DFS	Median	All	0.749	0.878	.002	28	view →
STAD	OS	Quartile	All	0.345	0.567	.023	21	view →
UVM	DFS	Median	II,III,IV	0.541	0.856	.017	20	view →
SARC	DFS	Median	All	0.279	0.486	.003	15	view →
LAML	DFS	Quartile	All	0.613	0.274	.020	14	view →
SKCM	OS	Median	IV	0.775	0.230	.008	11	view →
COAD	OS	Median	III,IV	0.877	0.691	.008	10	view →
THCA	DFS	Tertile	III,IV	0.861	0.994	.021	10	view →
THYM	OS	Median	II,III,IV	0.916	1.000	.015	9	view →
DLBC	OS	Tertile	All	0.310	1.000	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CORIN–LIHC (OS)

Open the LIHC breakdown →