CORIN

Across TCGA pan-cancer cohorts, CORIN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CORIN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CORIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CORIN is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where CORIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CORIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.945	<.001	12	view →
KIRC	Male	II,III,IV	−0.690	<.001	11	view →
KICH	All	All	−0.802	<.001	9	view →
BRCA	All	IV	+2.665	<.001	8	view →
KIRP	All	All	−0.525	<.001	7	view →
LIHC	Female	All	+0.074	.002	7	view →
READ	All	II,III,IV	+0.720	<.001	4	view →
STAD	All	II,III,IV	+0.567	<.001	4	view →
LUSC	Male	III,IV	−0.867	<.001	3	view →
CHOL	All	All	+0.423	<.001	3	view →
LUAD	Female	All	−0.392	.015	2	view →
PRAD	All	All	−0.272	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CORIN–COAD

Open the COAD breakdown →