CORIN

Across TCGA patient cohorts, CORIN mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORIN-associated genes across cancer lineages are CDK1, Rictor_pT1135, and STAT3_pY705. Each is linked with CORIN in more than 2 cancer types. Because this analysis shows association rather than direction, both CORIN-to-partner and partner-to-CORIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by CORIN-low versus CORIN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORIN→partner) and Y-score (partner→CORIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDK1 →	+0.152	+2.087	.005	.004	3	3
UCEC	Rictor_pT1135 →	-0.082	-1.584	.007	.002	3	3
UCEC	STAT3_pY705 →	-0.409	-2.137	<.001	<.001	3	3
UCEC	ASNS →	+0.292	+1.362	.006	.034	3	3
UCEC	4E-BP1 →	+0.317	+3.999	<.001	<.001	3	3
LUSC	14-3-3_epsilon →	+0.094	+2.486	.023	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

CDK1 by CORIN expression — SKCM

Explore this box plot interactively →